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‘This is my calling’: building point-of-care diagnostic tools to fight tuberculosis

Nature - 10 hours 22 min ago

Nature, Published online: 01 March 2024; doi:10.1038/d41586-024-00625-4

Mireille Kamariza talks about her journey from community college to biotech chief executive, and the uphill battle to stop the spread of the deadly lung disease.

Galapagos giant tortoises were supersized before arrival

Nature - Thu, 02/29/2024 - 00:00

Nature, Published online: 29 February 2024; doi:10.1038/d41586-024-00567-x

Fossil analysis suggests the reptiles were already huge when they rode ocean currents to the islands thousands or even millions of years ago.

Submerged volcano’s eruption was the biggest since the last ice age

Nature - Thu, 02/29/2024 - 00:00

Nature, Published online: 29 February 2024; doi:10.1038/d41586-024-00565-z

Some 7,300 years ago, the Kikai volcano in Japan produced up to 457 cubic kilometres of ash and other debris.

Mpox’s surge was stopped by behaviour change — before vaccine rollout

Nature - Thu, 02/29/2024 - 00:00

Nature, Published online: 29 February 2024; doi:10.1038/d41586-024-00566-y

Analysis of more than 1,000 viral genomes reveals patterns in how the disease circulated through various communities.

This dying star bears a jagged metal scar

Nature - Thu, 02/29/2024 - 00:00

Nature, Published online: 29 February 2024; doi:10.1038/d41586-024-00564-0

The surface of a white dwarf is marked with metallic patches — souvenirs of its encounter with an asteroid or planet.

Two giant US telescopes threatened by funding cap

Nature - Thu, 02/29/2024 - 00:00

Nature, Published online: 29 February 2024; doi:10.1038/d41586-024-00623-6

Thirty Meter Telescope and Giant Magellan Telescope might need to compete for survival in face of federal spending limit.

Robot, repair thyself: laying the foundations for self-healing machines

Nature - Thu, 02/29/2024 - 00:00

Nature, Published online: 29 February 2024; doi:10.1038/d41586-024-00597-5

Advances in materials science and sensing could deliver robots that can mend themselves and feel pain.

Editorial Expression of Concern: p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

Nature - Wed, 02/28/2024 - 00:00

Nature, Published online: 28 February 2024; doi:10.1038/s41586-024-07223-4

Editorial Expression of Concern: p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

Symmetry breaking and chiral amplification in prebiotic ligation reactions

Nature - Wed, 02/28/2024 - 00:00

Nature, Published online: 28 February 2024; doi:10.1038/s41586-024-07059-y

A study of a new route to proteinogenic peptides reveals how heterochiral preference can lead to homochiral peptides in a prebiotic world.

Anti-TIGIT antibody improves PD-L1 blockade through myeloid and T<sub>reg</sub> cells

Nature - Wed, 02/28/2024 - 00:00

Nature, Published online: 28 February 2024; doi:10.1038/s41586-024-07121-9

A high baseline of intratumoural macrophages and regulatory T cells is associated with better outcomes in patients with non-small cell lung cancer treated with atezolizumab plus tiragolumab, but not with atezolizumab alone.

The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

Nature - Wed, 02/28/2024 - 00:00

Nature, Published online: 28 February 2024; doi:10.1038/s41586-024-07112-w

The ubiquitin proteasomal system degrades nuclear cGAS in cycling cells.

Incomplete transcripts dominate the <i>Mycobacterium tuberculosis</i> transcriptome

Nature - Wed, 02/28/2024 - 00:00

Nature, Published online: 28 February 2024; doi:10.1038/s41586-024-07105-9

A study reveals that most transcripts in Mycobacterium tuberculosis are incomplete, likely because of the tendency of the transcription machinery in this species to pause on genomic DNA.

Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance

Nature - Wed, 02/28/2024 - 00:00

Nature, Published online: 28 February 2024; doi:10.1038/s41586-024-07108-6

Rhythmic neural activity drives cerebrospinal fluid perfusion through brain parenchyma to enhance brain cleansing.

Mutualisms weaken the latitudinal diversity gradient among oceanic islands

Nature - Wed, 02/28/2024 - 00:00

Nature, Published online: 28 February 2024; doi:10.1038/s41586-024-07110-y

The effect of the latitudinal diversity gradient on plants on oceanic islands is weakened by classical abiotic physical drivers of island biogeography and, to a greater extent, by mutualism with other species.

Durable and efficient gene silencing in vivo by hit-and-run epigenome editing

Nature - Wed, 02/28/2024 - 00:00

Nature, Published online: 28 February 2024; doi:10.1038/s41586-024-07087-8

Experiments in mice show that designed epigenome editors that contain domains of transcriptional repressors can enable stable epigenetic silencing of Pcsk9, a gene with a role in cholesterol homeostasis, without inducing DNA breaks.

Latitudinal patterns in stabilizing density dependence of forest communities

Nature - Wed, 02/28/2024 - 00:00

Nature, Published online: 28 February 2024; doi:10.1038/s41586-024-07118-4

An analysis of tree survival data from forest sites worldwide shows that in the tropics, rare tree species experience stronger stabilizing density dependence than common species, wheras no correlation of stabilizing density dependence and abundance exists in the temperate zone.

CST–polymerase α-primase solves a second telomere end-replication problem

Nature - Wed, 02/28/2024 - 00:00

Nature, Published online: 28 February 2024; doi:10.1038/s41586-024-07137-1

Incomplete duplication of the C-rich telomeric repeat strand by lagging-strand DNA synthesis is counteracted by DNA synthesis mediated by CST–polymerase α-primase.

Identifying general reaction conditions by bandit optimization

Nature - Wed, 02/28/2024 - 00:00

Nature, Published online: 28 February 2024; doi:10.1038/s41586-024-07021-y

Bandit optimization models are used to identify generally applicable conditions by efficient condition sampling and evaluation of experimental feedback.

Imaging the Meissner effect in hydride superconductors using quantum sensors

Nature - Wed, 02/28/2024 - 00:00

Nature, Published online: 28 February 2024; doi:10.1038/s41586-024-07026-7

In order to explore superconductivity in hydride materials, local magnetometry inside a diamond anvil cell is performed with sub-micron spatial resolution at megabar pressures using nitrogen-vacancy colour centres.

Ligand-channel-enabled ultrafast Li-ion conduction

Nature - Wed, 02/28/2024 - 00:00

Nature, Published online: 28 February 2024; doi:10.1038/s41586-024-07045-4

An electrolyte design using small-sized fluoroacetonitrile solvents to form a ligand channel produces lithium-ion batteries simultaneously achieving high energy density, fast charging and wide operating temperature range, desirable features for batteries working in extreme conditions.

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